Invited Speakers
Chun Xu, PhD
Senior Lecturer, Sydney Horizon Fellow
The University of Sydney
Dr. Chun Xu is a Sydney Horizon Fellow and senior lecturer at the University of Sydney. Previously, he held position as a senior lecturer and group leader at The University of Queensland (UQ). He earned his Ph.D. in Biomedical Engineering and anotechnology from UQ and completed postdoctoral training at University of California, Los Angeles (UCLA) and Stanford University in the United States. Dr. Xu obtained a B.D.S. in Dentistry and an M.D.S. in Oral and Maxillofacial Surgery from Wuhan University. With a prolific publication record, Dr. Xu has authored over 100 peer-reviewed scientific papers in prestigious journals, including Nature Nano., Angew. Chem, Adv. Mater., Chem. Mater., Small. Additionally, he holds several patents. His publications have garnered more than 6100 citations, with a h-index of 45. In addition to his research contributions, Dr. Xu serves as an editor on the ECR editorial boards of Nano-Micro Letters, National Science Review, Materials Today Bio, among others. He has been recognized with several awards, including the Young Tall Poppy Scientific Award, the Frontiers Rising Star Award, and the U21 Health Sciences Early Career Researcher Award.
Functional nanomaterials for dental and biomedical applications
Nanoparticles possess unique physical, chemical, and biological properties due to the nanosize effects and offer various advantages for biomedical applications, such as drug delivery and tissue engineering. Functional porous nanoparticles such as mesoporous silica nanoparticles are of special interest due to their good biocompatibility, high stability, rigid framework, well-defined pore structure, easily controllable morphology, and tunable surface chemistry. In this presentation, I will discuss our previous work and the recent progress in utilizing functional porous nanoparticles for dental and biomedical application including drug delivery, tissue engineering and anti-biofilm applications.
Mehmet Ali Darendeliler, BDS, PhD
Professor and Chair of Orthodontics
The University of Sydney
Dr Darendeliler is Professor and Chair of Orthodontic, Discipline of Orthodontics, at the University of Sydney.
He received his dentistry training from the University of Istanbul and his PhD from the University of Gazi, in Turkey and his first specialist training in orthodontics from the University of Geneva, Switzerland and his second specialist training from the High Education Council, Turkey.
During the course of his career he was a clinical instructor, research and postgraduate coordinator at the University of Geneva, Assistant Professor at the University of North Carolina, Research Professor at the University of Southern California.
Dr Darendeliler has been recognized for his efforts with multiple prizes including the “Sheldon Friel Award , the highest recognition from the European Orthodontic Society, the “Begg Award”, the highest research award from the Australian Society of Orthodontists, and the Huston award for best research from the European Orthodontic Society.
Innovative Research in Orthodontics / Sydney University
Dental caries is a complex, multifactorial disease in which dental plaque (oral biofilms) plays an important role. The accumulation of biofilms on tooth surfaces or restorative materials increases the risk of developing dental caries. Despite extensive studies on the effects of dental treatments on biofilm formation and development in antimicrobial materials, there is still considerable space for further investigation, particularly from a multidisciplinary perspective. This presentation will highlight findings from our research group, including the effects of tooth bleaching on biofilm formation on both human enamel and restorative materials, as well as the impact of silver diamine fluoride (SDF) treatment on dual-species biofilms of Streptococcus mutans and Candida albicans. Furthermore, we will discuss the development of novel antibiofilm agents that hold promise for clinical application.
Sirawut Hiran-us, DDS, MSc
Assistant Professor
Chulalongkorn University
Assistant Professor Sirawut Hiran-us obtained his Doctor of Dental Surgery, Master of Science in Endodontics, and Higher Graduate Diploma in Clinical Sciences (Endodontics) from the Faculty of Dentistry at Chulalongkorn University, Thailand. He is also a Diplomate of the Thai Board of Endodontics. In his academic role, he serves as an Assistant Professor in Endodontics in the Department of Operative Dentistry and as Assistant Dean for Strategic Planning in Research and Innovation at the Faculty of Dentistry, Chulalongkorn University. Professionally, he currently holds the position of Secretary of the Thai Endodontic Association and is a board committee member of the Thai Board of Endodontics at the Royal College of Dental Surgeons of Thailand.
Integrating Research and Clinical Practice in Endodontics
Modern dental practice is increasingly guided by Evidence-Based Dentistry (EBD), which emphasizes the utilization of the best available evidence as one of its foundational pillars. Clinicians frequently encounter a range of challenges that necessitate ongoing research to address these issues effectively. While some practices already meet high standards, further advancements can be achieved through research. This presentation will explore various research topics pertinent to Endodontics, encompassing both the fundamental properties and the strengthening strategies of nickel-titanium rotary files, the complexities of root canal anatomy influenced by various traits, and the current understanding of calcium silicate cements.
Masahide Takedachi, DDS, PhD
Professor
Osaka University
2004-2007 Associate Research Scientist, Immunobiology and Cancer Research Program, Oklahoma Medical Re search Foundation
2007-2008 COE Project Researcher, Department of Periodontology, Osaka University Graduate School of Dentistry
2008-2009 Medical Staff, Department of Periodontics and Endodontics, Osaka University Dental Hospital
2009-2010 Research Fellowship for Young Scientist of Japan Society for the Promotion of Science
2011-2017 Assistant Professor, Department of Periodontology, Osaka University Graduate School of Dentistry
2017-2024 Associate Professor, Department of Periodontics and Endodontics, Osaka University Dental Hospital
2024- Professor, Department of Periodontology and Regenerative Dentistry, Osaka University Graduate School of Dentistry
Development of new cell-based therapy for periodontal tissue regeneration
Periodontitis is a chronic inflammatory disease that leads destruction of periodontal tissue. Due to unsatisfied efficacy of current periodontal regenerative therapies, ‘true’ periodontal tissue engineering has to be established by development of new cell-based therapy.
We have focused on adipose tissue-derived multi-lineage progenitor cells (ADMPCs), which are highly purified mesenchymal stem cells inherent in adipose tissue. Our research has been dedicated to developing new periodontal tissue regeneration therapy through autologous transplantation of ADMPCs.
We first demonstrated that autologous transplantation of ADMPCs significantly induced the periodontal tissue regeneration in preclinical studies using experimental periodontitis models on beagle dogs. We then performed an exploratory phase I clinical study involving 12 patients with periodontitis. The safety and efficacy of this cell transplantation therapy were assessed through a 36-week post-transplantation follow-up. The clinical study revealed significant periodontal tissue regeneration 36 weeks after ADMPC transplantation. Notably, no severe adverse events related to cell transplantation were observed in any patients. During this clinical study, the inadequate space-making capability of the fibrin gel became a concern. To overcome this limitation, we opted for carbonate apatite (CaAp), a dental bone graft material, as a scaffold for the ADMPCs. We investigated the impact of CaAp on the cellular functions of ADMPCs in vitro and evaluated its efficacy using a canine periodontitis model. The results indicated that CaAp did not adversely affect the cell function of ADMPCs. Additionally, when using CaAp as a scaffold for ADMPC transplantation into a canine model of severe periodontal disease, high space-making ability and significant new attachment were observed. Based on these results, we are currently evaluating the efficacy of the autologous transplantation of ADMPCs using CaAp as a scaffold material. In this presentation, I would like to provide an overview of the progress made so far and discuss future perspectives.
Sung-Dae Cho, DVM, PhD
Professor
Associate Dean of Student Affairs
Seoul National University
Education
・Post-Doc: Department of Veterinary Physiology and Pharmacology, Texas A&M University
・Ph D: Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
・B.S.: College of Veterinary Medicine, Seoul National University (DVM)
Professional Experiences
・2023.01-Present: Associate Dean for Student affair, School of Dentistry, Seoul National University
・2016.09-Present: Professor, Department of Oral Pathology, School of Dentistry, Seoul National University
・2007.09-2016.08: Associate Professor, Department of Oral Pathology, School of Dentistry, Chonbuk National University
Publications
・Han JM, Oh KY, Choi SJ, Lee WW, Jin BH, Kim JH, Yu HJ, Kim RJY, Yoon HJ, Lee JI, Hong SD, Cho SD. (2024) Antitumor activity of afatinib in EGFR T790M-negative human oral cancer therapeutically targets mTOR/Mcl-1 signaling axis. Cellular Oncology,
・Ahn MH, Kim JH, Choi SJ, Kim HJ, Park DG, Oh KY, Yoon HJ, Hong SD, Lee JI, Shin JA, Cho SD. (2024) Neuropilin-2 acts a critical determinant for epithelial-to-mesenchymal transition and aggressive behaviors of human head and neck cancer. Cellular Oncology, 47(2):497-511
・Shin JA, Kim LH, Ryu MH, Choi SY, Jin B, Lee W, Jung YC, Ahn CH, Ahn MH, Hong KO, Swarup N, Chawla K, Kang SC, Hong SD, Cho SD. (2022) Withaferin A mitigates metastatic traits in human oral squamous cell carcinoma caused by aberrant claudin-1 expression. Cell Biology and Toxicology, 38(1):147-165
・Swarup N, Hong KO, Chawla K, Choi SJ, Shin JA, Oh KY, Yoon HJ, Lee JI, Hong SD, Cho SD. (2022) Effect of PAIP1 on the metastatic potential and prognostic significance in oral squamous cell carcinoma. International Journal of Oral Science. 14;14(1):9.
・Shin JA, Won DH, Swarup N, Ahn MH, Yang SO, Chawla K, Kim J, Choi SJ, Ahn CH, Oh KY, Yoon HJ, Lee JI, Hong SD, Hong KO, Cho SD. (2021) Methanol extract of Sedum oryzifolium and its constituent, trehalose, impede the invasiveness of oral squamous cell carcinoma cell lines via downregulation of Slug. Phytomedicine. 91:153670.
Molecular Target and Signaling Pathway for Oral Cancer
According to statistics from Korean National Cancer Center (2021), the probability of developing cancer in South Korea is estimated to be 38.1% if citizens live to their expected lifespan, suggesting that approximately 1 in 3 individuals will be diagnosed with cancer. In the case of oral cancer, however, out of 277,523 cancer patients in 2021, only 4,371 had oral cancer, accounting for about 1.6%. Despite this low incidence, the unique characteristics of the oral cavity can lead to significant challenges after surgery, including difficulties in speech, swallowing, and aesthetic issues due to changes in appearance, ultimately affecting patients’ quality of life. Thus, it is crucial to discover new prevention and treatment methods for oral cancer, despite its lower incidence rate compared to other cancers. Currently, cisplatin is the primary drug used for treating oral cancer, but like other conventional cytotoxic chemotherapy agents, it is not specific to cancer cells, leading to numerous side effects relative to its therapeutic effects.
Consequently, recent trends in chemotherapy research are shifting towards personalized treatments that reflect individual characteristics, with active research being conducted to identify personal risk factors associated with cancer. Studies aimed at identifying factors involved in tumor formation are part of this trend, as molecular targeting and the elucidation of related mechanisms are expected to yield more effective results with fewer side effects by selectively attacking specific targets based on the recently discovered characteristics of cancer cells. As a result, there is a growing global trend in biopharmaceutical research focused on developing molecular targets for cancer treatment based on molecular biology. This presentation aims to discuss the important contemporary issues surrounding the discovery of molecular targets and mechanisms for the prevention and treatment of oral cancer.
Ji-Man Park, DDS, MSD, PhD
Associate Professor,
Associate Dean of Planning & Coordination
Seoul National University
Ji-Man Park, has Graduated from Seoul National University in 2002. He trained at the department of prosthodontics, Seoul National University Dental Hospital. He gained Ph. D and Master’s degree at Seoul National University. He started working as an assistant professor at Ewha Womans University in 2009 and did his best on dental treatment, research and education until 2015. He was a clinical associate professor at Seoul National University Gwanak Dental Hospital from 2015 to 2017. He was a clinical associate professor at Yonsei University, College of Dentistry from 2017 to 2021. He has been an associate professor at Seoul National University, School of Dentistry since 2021.
He has studied digital dentistry and the clinical application of intraoral scanners and 3D printers. He also has worked on government research projects, “Standardisation of evaluation protocol for the performance comparison of digital intraoral scanners”, “Development of 3D printable ceramic material and associated printer”, and “Robotic system for implant surgery”.
Ji-Man Park is an active member of IADDM (International Academy of Digital Dental Medicine), IADR, AO, AAP, and works as an Editor-in-Chief of the Journal of implantology and applied sciences (JIAS).
Present) Associate Professor at School of Dentistry, Seoul National University
DDS, MSD, PhD from School of Dentistry, Seoul National University
Trained at Dept. of Prosthodontics, Seoul National University Dental Hospital
Assistant Professor at School of Medicine, Ewha Womans University & Ewha Mokdong Hospital
Clinical Associate Professor at Seoul National University Gwanak Dental Hospital
Professor at Yonsei University College of Dentistry
Associate Dean of Planning & Coordination, Seoul National University School of Dentistry
Head of Dental Device Usability Testing Center, Seoul National University Dental Hospital
・Editor-in-Chief of Journal of Implantology and Applied Sciences
・Secretary at ISO TC 106/SC 9/WG 7 (3D printing)
・Vice President of Digital Dentistry Research Network (DDRN) of International Association for Dental Research (IADR)
・Director of Academic Affairs at Korean Academy of Prosthodontics
Bridging Research and Practice: Pioneering Digital Solutions in Esthetic Dentistrye:
The landscape of esthetic dentistry is undergoing a significant transformation with the integration of digital technologies. This lecture presents an innovative approach that combines the advancements in intraoral scanners, AI-assisted CAD software, and advanced milling machines/3D printers to revolutionize diagnostic processes and treatment modalities in esthetic dentistry.
With the advent of high-precision intraoral scanners, the initial step of the digital workflow can be directly applied in the patient’s mouth, enabling a seamless transition into digital restorative dentistry. The incorporation of facial scans and intraoral scan data has further enhanced diagnostic accuracy, particularly in digital smile design. This lecture will explore the methodology of integrating digital information with the patient’s mandibular movements to design provisional and definitive prostheses that conform to the physiological motion path.
The discussion will extend to the utilization of dynamic mandibular movement within dental CAD software, showcasing how virtual patient models can improve dentist-patient interactions and facilitate full mouth rehabilitation. This technique promises a more accessible path to achieving ideal occlusion and function.
Attendees will be presented with various devices pivotal to digital dentistry’s evolution, emphasizing the enhanced cost-effectiveness and user-friendly interfaces of modern intraoral scanners. Clinical cases will be discussed to illustrate the profound impact of these technologies on dental practice, highlighting the synergy between digital information integration and mandibular movement utilization in achieving optimal esthetic and functional outcomes.
This lecture aims to provide a comprehensive understanding of the digital workflow in esthetic dentistry, from diagnosis to treatment, and to demonstrate the practicality and effectiveness of integrating digital technologies in daily dental practice.
Panida Thanyasrisung, DDS, PhD
Associate Professor
Chulalongkorn University
Panida graduated from the Faculty of Dentistry, Chulalongkorn University with a bachelor’s degree. She began her career as a dentist in Surin Province, Thailand, where she worked for approximately 1.5 years before returning to the Faculty of Dentistry, Chulalongkorn University as a lecturer. She earned a PhD in Dental Sciences from Tokyo Medical and Dental University under the supervision of Prof. Motoyuki Sugai, at the Department of Bacteriology, Graduate School of Biomedical Sciences, Hiroshima University. After completing her PhD, Panida’s research focuses on oral microbiology, particularly preventing dental caries. Her works range from basic science – exploring the interaction of dual-species and interkingdom biofilms between Streptococcus mutans and Candida spp. – to clinical applications through multidisciplinary collaboration, such as developing antibiofilm materials. She is currently an associate professor at the Department of Microbiology, Faculty of Dentistry, Chulalongkorn University.
Impact of Tooth Bleaching and Silver Diamine Fluoride on Biofilm Formation and Antibiofilm Strategies for Caries Prevention
Dental caries is a complex, multifactorial disease in which dental plaque (oral biofilms) plays an important role. The accumulation of biofilms on tooth surfaces or restorative materials increases the risk of developing dental caries. Despite extensive studies on the effects of dental treatments on biofilm formation and development in antimicrobial materials, there is still considerable space for further investigation, particularly from a multidisciplinary perspective. This presentation will highlight findings from our research group, including the effects of tooth bleaching on biofilm formation on both human enamel and restorative materials, as well as the impact of silver diamine fluoride (SDF) treatment on dual-species biofilms of Streptococcus mutans and Candida albicans. Furthermore, we will discuss the development of novel antibiofilm agents that hold promise for clinical application.
Masae Kuboniwa, DDS, PhD
Professor
Osaka University
ACADEMIC TRAINING
1988 B.Agr. – Kyoto University Faculty of Agriculture
1995 D.D.S. – Osaka University Faculty of Dentistry (Japanese dentist’s license No. 125661)
APPOINTMENTS
2016 – 2024 Associate Professor, Department of Preventive Dentistry, Course for Oral Sciences, Osaka University Graduate School of Dentistry
2024 – Present Professor and Department Chair, Department of Preventive Dentistry, Course for Oral Sciences, The University of Osaka Graduate School of Dentistry
PROFESSIONAL SERVICE
2010 – Present Editorial Board, Molecular Oral Microbiology
2023 – Present Associate Member, Science Council of Japan
2023 – Present Editorial Board, Journal of Periodontology
2024 – Present Standing Committee Member, The Society for Oral Health in Kinki, Chugoku and Shikoku
2024 – Present Director, The Japanese Society for Biofilm Research
HONORS
2014 Osaka University Presidential Award for Research Achievement, Osaka University
2015 Paper of the Week, The Journal of Biological Chemistry
2017 Lion Academic Award of The Japanese Society for Oral Health
2024 2024 Highly Cited Author, American Society for Microbiology
Pioneering the Future of Preventive Dentistry
Metabolomics is a powerful analytical tool that enables the comprehensive investigation of metabolic changes that may not be inferred from existing knowledge. It is particularly valuable for identifying novel biomarkers with potential to directly inform disease diagnosis and severity assessment. In the context of periodontal disease, changes in disease severity are often accompanied by alterations in enzyme activity within the subgingival environment – a consortium comprising periodontal tissues and the adjacent subgingival microbiota. These enzymatic changes lead to distinct shifts in metabolite profiles, which can be detected in both saliva and blood.
In our recent study, we developed a predictive model for inflammation associated with periodontal disease by performing metabolomic profiling of saliva specimens. The model was constructed using the Periodontal Inflamed Surface Area (PISA), a quantitative indicator of periodontal disease severity, as an objective variable. Our results revealed an upregulation of polyamine metabolic pathways in the biofilms of patients with periodontal disease, with polyamines such as cadaverine and putrescine being significantly elevated in saliva. In vitro studies further indicated that putrescine not only promotes biofilm formation by Porphyromonas gingivalis, a key periodontal pathogen, but also enhances the dispersal of biofilm-forming bacteria, thereby accelerating the biofilm life cycle.
Based on these findings, we propose that salivary polyamines may serve as candidate biomarkers for monitoring the progression of periodontal disease. We are working towards the development of a highly accurate screening tool for periodontal disease through the simultaneous analysis of salivary polyamines for the purpose of public health usage. Additionally, our research demonstrates that salivary metabolites can effectively screen for diabetes, achieving accuracy comparable to blood-based tests. This will enable general dentists to recommend patients undergo further medical examinations by physician.