Interdisciplinary Dentistry (Department of Interdisciplinary Dentistry)

Division for Interdisciplinary Dentistry focuses on “many questions in dental treatment”, and work on basic and clinical research on interdisciplinary.

ProfessorTadashi NAGASHIMA
Associate ProfessorTakenori NOZAKI
Associate ProfessorJiro MIURA

■ Interdisciplinary Researches for future clinical practice

Our main themes are

  1. Dentinal modification and physiological changes with human aging
  2. Structural characterization of the materials and hard tissues interface
  3. Relationship between the pulp environment and metabolic diseases
  4. Multiscale research of tooth fracture

 We have particular interest in micro- and nano- structural observation for dentistry. In particular, three-dimensional observation of mineralized hard tissue using tomography, with nano fabrication technique (focus ion beam) and ultra-high voltage electron tomography has been attracting attention as a new method of structural analysis (Dent. Mater. 2013). These research provide pure evidences for clinical treatment.

 We are conducting research to observe the deposition of glycation end products (AGEs), age-related substances. In 2014, we were the first in the world to successfully detect the localization of AGEs in human dentin (Arch. Oral. Biol. 2014), and we know that dentin is affected by metabolic disease such as diabetes mellitus and is related to the mechanism of chronic caries development (Biomed. Opt. Exp. 2015, J Dent. Res. 2016). This research is attracting attention as research that will expand into various fields, including aging medicine.

lmmunohistochemical staining of human dentin with the anti-AGEs antibody

(Arch. Oral. Biol. 2014)

Distribution of fluorescence intensity and average fluorescence lifetime of young and aged dentin sections.

(Biomed. Opt. Exp. 2015)

The images of ultra-high voltage electron microscope.

Upper: Coronal bond–dentin interface,

Lower: Apical bond–dentin interface

(Dent. Mater. 2013)