Oral & Maxillofacial Oncology and Surgery 

 We are teaching most oral diseases, including of odontogenic inflammation, oral cancer, malformation of lip and palate, deformity of cancer, malformation of lip and palate, deformity of jaw bones, trauma, diseases of oral mucosa, cystic lesions,atrophy of alveolar ridge,temporomandibular joint disease(TMD), and disease of the salivary gland.

 Our major titles in the research and clinical fields in Graduate School of Dentistry are oral oncology and advanced method for oral and maxillofacialsurgery.

ProfessorNarikazu UZAWA
Associate ProfessorKazuhide MATSUNAGA
Assistant ProfessorMasakazu HAMADA
Assistant ProfessorAkinori TAKESHITA
Assistant ProfessorYoshiro MORITA

■ Education

 Major lecture contents for the students of School of Dentistry are oral oncology, principle of surgical treatment for oral diseases, practical method for tooth extraction, hematology associated with oral surgery, infection control, neurological diseases, and implant surgery.

 In advanced sections we provide special lectures concerning the management of jaw bone fracture, cleft lip and cleft palate, surgical orthodontics, treatment of oral cancer,treatment of TMD, and treatment of oral mucosal diseases.

■ Research Activities

The role of GATA gene expression in oral cancer

Expression of the GATA gene in various cancer tissues hasbeen reported. Some GATA gene is used as a marker indiagnosis (ex. GATA3 in breast cancer), but there are manyunclear points regarding its expression. In our department,we are analyzing the expression of GATA gene in oral cancer tissues by molecular biology.

Elucidation of the mechanism of lymph node metastasis in oral cancer

 It is known that the cervical lymph node metastasis greatly affects the prognosis in the treatment of oral cancer. In this department, to elucidate the mechanism of the cervical lymph node metastasis we analyze it using an animal model of oral cancer cervical lymph node metastasis. Also, we conducting research aiming to develop new oral cancer treatment.

(Yoshihiro M. et al. Clin Exp Metastasis 2015, 32:739–753.)

Development of novel molecular targeted therapy for oral cancer

 The development of new molecular targeted therapeutic agents for cancer treatment is ongoing in whole world. In our department, we are also researching some new target genes for cancer treatment. As one of them, we are conducting basic research aiming for clinical application of nucleic acid drugs targeting E-selectin in collaboration with Oklahoma University in USA.

(Yoshihiro M. et al. Cancers 2020, 12, 725.)

The research of cancer microenvironment using 3D tissue culture model

 It is known that the microenvironment surrounding cancer cells is important for treatment not only of oral cancer but also of various malignant tumors. In our lab, we are collaborating with other laboratories and we conduct three-dimensional culture using some special methods to research oral cancer.

 This makes it possible to reproduce tissue structures such as epithelium and blood vessels in vitro.

(Kyoko N. et al. Tissue Eng Part C Methods 2019, 25:262-275.)

Boron Neutron Capture Therapy (BNCT)

BNCT is a treatment method in which Boron 10is incorporated into tumor cells in advance and neutron rays are applied to destroy only those tumor cells. Formerly used a nuclear reactor to generate this neutron beam, but now the development of an accelerator for generating neutron beam is progressing. In this Lab, we are conducting research on this next-generation BNCT in collaboration with other facilities

The research on immune cells in oral cancer

In recent years, various roles of immune cells in tumors have been elucidated in cancer treatment. In our department, we are conducting collaborative research with the Graduate School of Medicine, Osaka University, using flow cytometry to analyze the immune cells in operated tumor tissue at the Oral Cancer Center as a sample.