Publications – Dept of Tissue and Developmental Biology
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Prof. Shinsuke Ohba
View complete publications on Google Scholar
https://scholar.google.com/citations?hl=en&user=jQKrmaQAAAAJ&view_op=list_works&sortby=pubdate
Selected publications
*corresponding author
| 1. | Tani S*, Okada H, Onodera S, Chijimatsu R, Seki M, Suzuki Y, Xin X, Rowe DW, Saito T, Tanaka S, Chung UI, Ohba S*, Hojo H*: Stem-cell-based modeling and single-cell multiomics reveal gene regulatory mechanisms underlying human skeletal development. Cell Rep 42(4):112276, 2023 |
| 2. | Hojo H*, Saito T, He X, Guo Q, Onodera S, Azuma T, Koebis M, Nakao K, Aiba A, Seki M, Suzuki Y, Okada H, Tanaka S, Chung UI, McMahon AP, Ohba S*: Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages. Cell Rep 40(10):111315, 2022 |
| 3. | Hojo H, Ohba S*: Sp7 action in the skeleton: its mode of action, functions, and relevance to skeletal diseases. Int J Mol Sci 23(10):5647, 2022 (review) |
| 4. | Ohba S*: Hedgehog signaling in skeletal development: Roles of Indian hedgehog and the mode of its action. Int J Mol Sci 21(18):6665, 2020 (review) |
| 5. | Onodera S, Saito A, Hojo H, Nakamura T, Zujur D, Watanabe K, Morita N, Hasegawa D, Masaki H, Nakauchi H, Nomura T, Shibahara T, Yamaguchi A, Chung UI, Azuma T*, Ohba S*: Hedgehog activation regulates human osteoblastogenesis. Stem Cell Reports 15(1):125-139, 2020 |
| 6. | Zujur D, Kanke K, Lichtler AC, Hojo H, Chung UI, Ohba S*: Three-dimensional system enabling the maintenance and directed differentiation of pluripotent stem cells under defined conditions. Sci Adv 3(5):e1602875, 2017 |
| 7. | Hojo H, McMahon AP, Ohba S*: An emerging regulatory landscape for skeletal development. Trends Genet 32(12):774-787, 2016 (review) |
| 8. | Kashiwagi M, Hojo H, Kitaura Y, Maeda Y, Aini H, Takato T, Chung UI, Ohba S*: Local administration of a hedgehog agonist accelerates fracture healing in a mouse model. Biochem Biophys Res Commun 479(4):772-778, 2016 |
| 9. | Aini H, Itaka K*, Fujisawa A, Uchida H, Uchida S, Fukushima S, Kataoka K, Saito T, Chung UI, Ohba S*: Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment. Sci Rep 6:18743, 2016 |
| 10. | Ohba S*: Hedgehog signaling in endochondral ossification. J Dev Biol 4(2):20, 2016 (review) |
| 11. | He X†, Ohba S†, Hojo H, McMahon AP*: AP-1 family members act with Sox9 to promote chondrocyte hypertrophy. Development 143(16):3012-3023, 2016 (†equal contribution) |
| 12. | Hojo H, Ohba S, He X, Lai LP, McMahon AP*: Sp7/Osterix is restricted to bone-forming vertebrates where it acts as a Dlx co-factor in osteoblast specification. Dev Cell 37(3):238-253, 2016 |
| 13. | Ohba S*†, He X†, Hojo H, McMahon AP*: Distinct transcriptional programs underlie Sox9 regulation of the mammalian chondrocyte. Cell Rep 12(2):229-243, 2015 (†equal contribution) |
| 14. | Maeda Y, Yamamoto K, Yamakawa A, Aini H, Takato T, Chung UI, Ohba S*: The H2 blocker famotidine suppresses progression of ossification of the posterior longitudinal ligament in a mouse model. RMD Open 1:e000068, 2015 |
| 15. | Kanke K, Masaki H, Saito T, Komiyama Y, Hojo H, Nakauchi H, Lichtler AC, Takato T, Chung UI, Ohba S*: Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free conditions. Stem Cell Reports 2(6):751-760, 2014 |
| 16. | Kitaura Y, Hojo H, Komiyama Y, Takato T, Chung UI, Ohba S*: Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice. PLoS ONE 9(10):e109597, 2014 |
| 17. | Yano F*, Ohba S, Hosaka Y, Saito T, Chung UI: Disease-modifying effects of TD-198946 on progressed osteoarthritis in a mouse model. Ann Rheum Dis 73(11):2062-2064, 2014 |
| 18. | Zhang X†, Peterson KA, Liu XS, McMahon AP*, Ohba S†: Gene regulatory networks mediating canonical Wnt signal directed control of pluripotency and differentiation in embryo stem cells. Stem Cells 31(12):2667-2679, 2013 (†equal contribution) |
| 19. | Maeda Y, Hojo H, Shimohata N, Choi S, Yamamoto K, Takato T, Chung UI, Ohba S*: Bone healing by sterilizable calcium phosphate tetrapods eluting osteogenic molecules. Biomaterials 34(22):5530-5537, 2013 |
| 20. | Hojo H*, Ohba S*, Taniguchi K, Shirai M, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Mishina Y, Yamada M, Konno T, Takato T, Kawaguchi H, Kambara H, Chung UI: Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium. J Biol Chem 288(14):9924-9932, 2013 |
| 21. | Komiyama Y*, Ohba S*, Shimohata N, Nakajima K, Hojo H, Yano F, Takato T, Docheva D, Shukunami C, Hiraki Y, Chung UI: Tenomodulin expression in the periodontal ligament enhances cellular adhesion. PLoS ONE 8(4): e60203, 2013 |
| 22. | Hojo H*, Ohba S*, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Takato T, Kawaguchi H, Chung UI: Gli1 protein participates in the hedgehog-mediated specification of the osteoblast lineage during endochondral ossification. J Biol Chem 287(21):17860-17869, 2012 |
| 23. | Yamamoto K, Hojo H, Koshima I, Chung UI, Ohba S*: Famotidine suppresses osteogenic differentiation of tendon cells in vitro and pathological calcification of tendon in vivo. J Orthop Res 30(12):1958-1962, 2012 |
| 24. | Ohba S*, Kawaguchi H, Kugimiya F, Ogasawara T, Kawamura N, Saito T, Ikeda T, Fujii K, Miyajima T, Kuramochi A, Miyashita T, Oda H, Nakamura K, Takato T, Chung UI*: Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity. Dev Cell 14(5):689-699, 2008 |
| 25. | Ohba S, Nakajima K, Komiyama Y, Kugimiya F, Igawa K, Itaka K, Moro T, Nakamura K, Kawaguchi H, Takato T, Chung UI*: A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner. Biochem Biophys Res Commun 357(4):854-860, 2007 |
| 26. | Akune T, Ohba S, Kamekura S, Yamaguchi M, Chung UI, Kubota N, Terauchi Y, Harada Y, Azuma Y, Nakamura K, Kadowaki T, Kawaguchi H*: PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 113(6):846-855, 2004 |
| 27. | Long F†, Chung UI†, Ohba S, McMahon J, Kronenberg HM, McMahon AP*: Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131(6):1309-1318, 2004 (†equal contribution) |
Assoc. Prof. Takashi Maeda
Selected publications
| 1. | Maeda T, Abe M, Kurisu K, Jikko A, Furukawa S. Molecular cloning and characterization of a novel gene, CORS26, encoding a putative secretory protein and its possible involvement in skeletal development. J Biol Chem 276: 3628-3634, 2001 |
| 2. | Maeda T, Alexander CM, Friedl A. Induction of syndecan-1 expression in stromal fibroblasts promotes proliferation of human breast cancer cells. Cancer Res 64(2):612-621, 2004 |
| 3. | Maeda T, Jikko A, Abe M, Yokohama-Tamaki T, Akiyama H, Furukawa S, Takigawa M, Wakisaka S. Cartducin, a paralog of Acrp30/adiponectin is induced during chondrogenic differentiation and promotes proliferation of chondrogenic precursors and chondrocytes. J Cell Physiol 206(2):537-544, 2006 |
| 4. | Maeda T, Desouky J, Friedl A. Syndecan-1 expression by stromal fibroblasts promotes breast carcinoma growth in vivo and stimulates tumor angiogenesis. Oncogene 25(9):1408-1412, 2006 |
| 5. | Akiyama H, Furukawa S, Wakisaka S, Maeda T. Cartducin stimulates mesenchymal chondroprogenitor cell proliferation through both extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt pathways. FEBS J 273(10): 2257-2263, 2006 |
| 6. | Akiyama H, Otani M, Sato S, Toyosawa S, Furukawa S, Wakisaka S, Maeda T. A novel adipokine C1q/TNF-related protein 1 (CTRP1) regulates chondrocyte proliferation and maturation through the ERK1/2 signaling pathway. Mol Cell Endocrinol 369(1-2):63-71, 2013 |
Assoc. Prof. Makoto Abe
Selected publications
| 1. | Saeki N, Inui-Yamamoto C, Ikeda Y, Kanai R, Hata K, Itoh S, Inubushi T, Akiyama S, Ohba S, Abe M. Deletion of Trps1 regulatory elements recapitulates postnatal hip joint abnormalities and growth retardation of Trichorhinophalangeal syndrome in mice. Hum Mol Genet 33(18):1618-1629, 2024 |
| 2. | Saeki N, Itoh Y, Kanai R, Itoh S, Inubushi T, Akiyama S, Inui-Yamamoto C, Abe M. Pregnane X receptor (PXR) represses osteoblast differentiation through repression of the Hedgehog signaling pathway. Exp Cell Res 416(1):113156, 2022 |
| 3. | Inubushi T, Nakanishi Y, Abe M, Takahata Y, Nishimura R, Kurosaka H, Irie F, Yamashiro T, Yamaguchi Y. The cell surface hyaluronidase TMEM2 plays an essential role in mouse neural crest cell development and survival. PloS Genet 18(7):e1009765, 2022 |
| 4. | Saeki N, Inui-Yamamoto C, Kuraki M, Itoh S, Inubushi T, Okamoto M, Akiyama S, Wakisaka S, Abe M. Senescence-accelerated mouse prone 8 (SAMP8) mice exhibit reduced entoconid in the lower second molar. Arch Oral Biol 128:105172, 2021 |
| 5. | Ono R*, Abe M*, Koike N, Inokawa H, Tuchiya Y, Umemura Y, Sasawaki Y, Yamamoto T, Wakisaka S, Kanamura N, Yagita K. Quantitative morphometric analysis of molar teeth and alveolar bone in aged mice using micro-computed tomography. J Oral Biosci 63(3):265-270, 2021 (*co-first authors) |
| 6. | Abe M, Cox TC, Firulli AB, Kanai SM, Dalhka J, Lim KC, Engel DJ, Clouthier DE. Gata3 is essential for separating patterning domains during facial morphogenesis. Development 148(17):dev199534, 2021 |
| 7. | Itoh Y, Itoh S, Naruse H, Kagioka T, Abe M, Hayashi M. Intracellular density is a novel indicator of different stages of murine osteoblast lineage cells. J Cell Biochem 122(12):1805-1816, 2021 |
| 8. | Naruse H, Itoh S, Itoh Y, Kagioka T, Abe M, Hayashi M. The Wnt/β-catenin signaling pathway has a healing ability for periapical periodontitis. Sci Rep 11(1):19673, 2021 |
| 9. | Nakamura E, Hata K, Takahata Y, Kurosaka H, Abe M, Abe T, Kihara M, Komori T, Kobayashi S, Murakami T, Inubushi T, Yamashiro T, Yamamoto S, Akiyama H, Kawaguchi M, Sakata N, Nishimura R. Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix. Commun Biol 4(1):1258, 2021 |
| 10. | Takeuchi Y, Tatsuta S, Kito A, Fujikawa J, Itoh S, Itoh Y, Akiyama S, Yamashiro T, Wakisaka S, Abe M. Kruppel-Like Factor 4 upregulates Matrix Metalloproteinase 13 expression in chondrocytes via mRNA stabilization. Cell Tissue Res 382(2):307-319, 2020 |
| 11. | Takeuchi Y, Kito A, Itoh S, Naruse H, Fujikawa J, Sadek K, Akiyama S, Yamashiro T, Wakisaka S, Abe M. Kruppel-Like Factor 4 represses osteoblast differentiation via ciliary Hedgehog signaling. Exp Cell Res 371(2):417-425, 2018 |
| 12.. | Yamauchi Y, Itoh S, Naruse H, Itoh Y, Abe M, Kagioka T, Hayashi M. HipOP mesenchymal population has high potential for repairing injured peripheral nerves. J Cell Biochem 119(6):4836-4844, 2018 |
| 13. | Fujikawa J, Takeuchi Y, Nomir AG, Kito A, Elkhashab E, Ghaleb A, Yang V, Akiyama S, Morisaki I, Yamashiro T, Wakisaka S, Abe M. Kruppel-like factor 4 regulates matrix metalloproteinase and aggrecanase gene expression in chondrocytes. Cell Tissue Res 370(3):441-449, 2017 |
| 14. | Nomir AG, Takeuchi Y, Fujikawa J, Elsharaby AA, Wakisaka S, Abe M. Fate mapping of Trps1 daughter cells during cardiac development using novel Trps1-Cre mice. Genesis 54(7):379-388, 2016 |
| 15. | Fujikawa J, Tanaka M, Itoh S, Fukushi T, Kurisu K, Takeuchi Y, Morisaki I, Wakisaka S, Abe M. Kruppel-like factor 4 expression in osteoblasts represses osteoblast-dependent osteoclast formation. Cell Tissue Res 358(1):177-187, 2014 |
| 16. | Yoshioka S, Takahashi Y, Abe M, Michikami I, Imazato S, Wakisaka S, Hayashi M, Ebisu S. Activation of the Wnt/β-catenin pathway and tissue inhibitor of metalloprotease 1 during tertiary dentinogenesis. J Biochem 153(1):43-50, 2013 |
| 17. | Michikami I, Fukushi T, Tanaka M, Egusa H, Maeda Y, Ooshima T, Wakisaka S, Abe M. Kruppel-like factor 4 regulates membranous and endochondral ossification. Exp Cell Res 318(4):311-325, 2012 |
| 18. | Michikami I, Fukushi T, Honma S, Yoshioka S, Itoh S, Muragaki Y, Kurisu K, Ooshima T, Wakisaka S, Abe M. Trps1 is necessary for normal temporomandibular joint development. Cell Tissue Res 348(1):131-140, 2012 |
| 19. | Abe S, Namba N, Abe M., Fujiwara M, Aikawa T, Kogo M, Ozono K. Monocarboxylate Transporter 10 Functions as a Thyroid Hormone Transporter in Chondrocytes. Endocrinology 153(8):4049-4058, 2012 |
| 20. | Miyajima H, Matsumoto T, Sakai T, Yamaguchi S, An SH, Abe M, Wakisaka S, Lee KY, Egusa H, Imazato S. Hydrogel-based biomimetic environment for in vitro modulation of branching morphogenesis. Biomaterials 32(28):6754-6763, 2011 |
| 21. | Abe M, Michikami I, Fukushi T, Abe A, Maeda Y, Ooshima T, Wakisaka S. Hand2 regulates chondrogenesis in vitro and in vivo. Bone 46(5):1359-1368, 2010 |
| 22. | Abe M, Maeda T, Wakisaka S. Retinoic acid affects craniofacial patterning by changing Fgf8 expression in the pharyngeal ectoderm. Dev Growth Differ 50:717-729, 2008 |
| 23. | Hendershot TJ, Liu H, Sarkar AA, Giovannucci DR, Clouthier DE, Abe M, Howard MJ. Expression of Hand2 is sufficient for neurogenesis and cell type-specific gene expression in the enteric nervous system. Dev Dyn 236(1):93-105, 2007 |
| 24. | Abe M, Ruest LB, Clouthier DE. Fate of cranial neural crest cells during craniofacial development in endothelin-A receptor-deficient mice. Int J Dev Biol 51(2):97-105, 2007 |
| 25. | Reinhold MI, Abe M, Kapadia RM, Liao Z, Naski MC. FGF18 represses noggin expression and is induced by calcineurin. J Biol Chem 279(37):38209-38219, 2004 |
| 26. | Abe M, Naski MC. Regulation of sprouty expression by PLCgamma and calcium-dependent signals. Biochem Biophys Res Commun 323(3):1040-1047, 2004 |
| 27. | Abe M, Tamamura Y, Yamagishi H, Maeda T, Kato J, Tabata MJ, Srivastava D, Wakisaka S, Kurisu K. Tooth-type specific expression of dHAND/Hand2: possible involvement in murine lower incisor morphogenesis. Cell Tissue Res 310(2):201-212, 2002 |
| 28. | Noguchi H, Kaname T, Sekimoto T, Senba K, Nagata Y, Araki M, Abe M, Nakagata N, Ono T, Yamamura K, Araki K. Naso-maxillary deformity due to frontonasal expression of human transthyretin gene in transgenic mice. Genes Cells 7(10):1087-1098, 2002 |
| 29. | Liu JG, Tabata MJ, Fujii T, Ohmori T, Abe M, Ohsaki Y, Kato J, Wakisaka S, Iwamoto M, Kurisu K. Parathyroid hormone-related peptide is involved in protection against invasion of tooth germs by bone via promoting the differentiation of osteoclasts during tooth development. Mech Dev 95(1-2):189-200, 2000 |